Increased Human Chorionic Gonadotropin Due to Hypogonadism
نویسندگان
چکیده
nonsignificant differences between cutoffs for serum and plasma and between assays are encouraging regarding the ease of interpretation by clinicians and laboratories. Also encouraging were improvements in the analytical sensitivity of these newergeneration assays. Interestingly, only 3 samples were identified as above the 99th percentile by all 3 assays. The mechanisms responsible for this lack of agreement are not known, but antibody differences and the cTnI epitopes recognized on the different circulating cTnI forms are the most likely causes (4 ). The discrepancies between assays in regard to individual samples identified as above the 99th percentile raise questions as to whether healthy individuals can be better characterized for use in defining reference limits. A prototype cTnI assay has shown sensitivity to 0.001 g/L with gaussian-distributed results (3 ). As assays become more sensitive, increasing numbers of MIs will be detected, but an increased prevalence of myocardial injury not related to ischemic pathologies will also be seen (5 ). The latter may complicate schemes for selecting healthy individuals when defining reference limits. The 99th percentile reference cutoffs derived here in 2 large apparently healthy populations for 3 2nd-generation cTnI assays should prove useful in clinical practice.
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